Pediatric Respirology and Critical Care Medicine

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 4  |  Issue : 3  |  Page : 37--40

Serum adenosine deaminase and tuberculin skin test in children with tuberculosis contact


Wanaporn Anuntaseree, Waroon Tangjitrapitak, Hansa Sriphongphankul, Kanokpan Ruangnapa, Kantara Saelim, Pharsai Prasertsan 
 Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand

Correspondence Address:
Wanaporn Anuntaseree
Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110
Thailand

Background: The tuberculin skin test (TST) is used in children who have been in contact with tuberculosis (TB). The test has limitations in terms of operator variability and the need for a second visit at 48–72 h for interpretation. Serum adenosine deaminase (ADA) was studied in adults and found to have a strong correlation with TST. Until now no data are available in the pediatric population. Objective: To examine the correlation between serum ADA and the TST in children who had been in contact with TB. Materials and Methods: A prospective study was conducted at Songklanagarind Hospital in southern Thailand among children aged 2–15 years with a history of contact TB between 2016 and 2018. Serum ADA was obtained before performing the TST. Children with active TB disease were excluded from the analysis. Results: Sixty-seven children were enrolled. The serum ADA ranged from 9.3–43 IU/L. The overall correlation between serum ADA and TST was poor (ρ = −0.03, P = 0.84). However, a subgroup analysis excluding 32 children with TST size 0 mm and a high variation of serum ADA (10–37.6 IU/L) found that in the remaining children, serum ADA and TST had a moderate correlation with statistical significance (ρ = 0.48, P = 0.004). Conclusions: The correlation between serum ADA and TST in contact TB pediatric patients was poor. The cause of low correlation was due to a high variability of serum ADA level in children who had no reaction to TST.


How to cite this article:
Anuntaseree W, Tangjitrapitak W, Sriphongphankul H, Ruangnapa K, Saelim K, Prasertsan P. Serum adenosine deaminase and tuberculin skin test in children with tuberculosis contact.Pediatr Respirol Crit Care Med 2020;4:37-40


How to cite this URL:
Anuntaseree W, Tangjitrapitak W, Sriphongphankul H, Ruangnapa K, Saelim K, Prasertsan P. Serum adenosine deaminase and tuberculin skin test in children with tuberculosis contact. Pediatr Respirol Crit Care Med [serial online] 2020 [cited 2021 Jun 19 ];4:37-40
Available from: https://www.prccm.org/article.asp?issn=2543-0343;year=2020;volume=4;issue=3;spage=37;epage=40;aulast=Anuntaseree;type=0