Pediatric Respirology and Critical Care Medicine

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 4  |  Issue : 1  |  Page : 2--7

Serum nonenzymatic anti-oxidants in Nigerian children with severe pneumonia: Association with complications and hospital outcomes


Bankole Peter Kuti, Oyeku Akibu Oyelami 
 Department of Paediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria

Correspondence Address:
Bankole Peter Kuti
Department of Paediatrics and Child Health, Obafemi Awolowo University, Ile-Ife
Nigeria

Background: Tissue damaging effects of free radicals generated during the acute inflammation processes of childhood pneumonia may be ameliorated by antioxidants. This study aimed to determine the serum non-enzymatic antioxidants {Total Phenols, Carotenoids, Flavoids, Ascorbic acid, Tocopherols and Total Antioxidant Contents (TAC)} of Nigerian children with or without severe pneumonia (SP) and relate these to the presence of parapneumonic effusions (PPE) and length of hospitalisation (LOH). Methods: Consecutive children two months to 14 years admitted with severe pneumonia and their age and sex matched controls were recruited over a 12-month period at a Nigerian Health facility. Serum antioxidants were assayed using chromatography method and related to PPE and LOH. Results: The majority (86.1%) of the 144 children (72 each with SP and controls) were under-fives and eight (11.1%) of SP group had PPE. Median (IQR) LOH was 5.0 (4.0 – 7.0) days and 45 (62.5%) had prolonged (≥5 days) hospital stay with 3 (4.2%) mortality. Serum Tocopherols, 10.1 (4.7) vs. 13.2 (7.6) µg/dl; total flavoids 1.0 (0.6) vs. 1.3 (0.8) µg/dl and TAC 6.1 (4.4-8.9) vs. 7.4 (5.0 – 13.3) ng/dl were significantly lower in children with SP (p < 0.05). Serum antioxidants levels were not related to the PPE, however children with prolonged LOH had lower TAC (p<0.05), which also correlated negatively with LOH (r =- 0.418; p < 0.001) Conclusion: Lower serum antioxidants observed in children with severe pneumonia may connote increased demand or increased predisposition to the infection. Antioxidant supplementation may aid recovery of Nigerian children with SP.


How to cite this article:
Kuti BP, Oyelami OA. Serum nonenzymatic anti-oxidants in Nigerian children with severe pneumonia: Association with complications and hospital outcomes.Pediatr Respirol Crit Care Med 2020;4:2-7


How to cite this URL:
Kuti BP, Oyelami OA. Serum nonenzymatic anti-oxidants in Nigerian children with severe pneumonia: Association with complications and hospital outcomes. Pediatr Respirol Crit Care Med [serial online] 2020 [cited 2021 Mar 2 ];4:2-7
Available from: https://www.prccm.org/article.asp?issn=2543-0343;year=2020;volume=4;issue=1;spage=2;epage=7;aulast=Kuti;type=0